Evaluation of <i>Hibiscus sabdariffa</i> Aerial Parts against Pyloric Ligation-induced Ulcers in Experimental Rats

Abstract

The sloughing off inflammatory dead tissue is characteristic of ulcers, which are open sores of the skin or mucous membrane. Peptic ulcers are erosive lesions on the stomach or duodenal lining. The drive of the study was to evaluate the effectiveness of Hibiscus sabdariffa aerial parts extracts against pylorus ligation-induced ulcers. The extracts were prepared by maceration using ethanol and double distilled water. In the treatment schedule, Groups A and B were considered negative and standard (Lansoprazole 8 mg/kg b. wt, p.o.) controls. Groups C, D, E, and F as low (200 mg/kg b. wt, p.o.) and high (400 mg/kg b. wt, p.o.) dose treatment groups, received EEHS and AEHS, respectively. Gastric content, pH, free and total acidity, ulcer index, and inhibition of ulcer (%) were assessed. Following administration of both extracts, measurements of stomach content, free and total acidity, and ulcer index decreased. Additionally, pH increased, and a greater percentage of ulcers were inhibited. It was discovered that the ethanolic extract had significantly higher anti-ulcer action than the aqueous extract.