Phenolic Content, Antioxidant, Hemidiaphragm Glucose Consumption, and Hemoglobin Glycosylation Inhibitory Activities of <i>Lavandula stoechas</i> L. Aqueous Extract

Abstract

The aqueous extract of Lavandula stoechas (AqLs) is employed as a diabetic cure in Eastern Moroccan traditional medicine. The aim of this study was to confirm and search for the antidiabetic mechanisms of this plant. The goal of this research is to look into the in vitro antioxidant activity of L. stoechas’s aqueous extract which was analyzed by using two different techniques; 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), and β-carotene bleaching assay, with an IC50 = 0.031 ± 0.02 mg/mL and an IC50 = 94.33 ± 12.5 µg/ml respectively. Furthermore, the polyphenolic and flavonoid concentrations were calculated at 146.71 ± 0.53 mg GAE/mg of AqLs, and 721,21 ± 0,21 µg QE/mg of AqLs respectively. Besides, the in vitro research of glucose consumption by Peripheral glucose consumption reveals that the combination of this extract, plus insulin, enhances the activity of insulin and improves glucose utilization by the hemidiaphragm with 166.89 ± 23.56 mg/g/h. Finally, the in vitro hemoglobin glycosylation test validated L. stoechas antidiabetic efficacy with activity equal to 48.94 ± 3.67 mg/mL compared to the gallic acid. Consequently, the aqueous extract of L. stoechas was discovered to have promising antidiabetic and antioxidant properties in this research, which can be considered for more biological exploration.