Evaluation of Wound Healing Activity of <i>Vernonia amygdalina</i> Extract in Diabetic Rats

Abstract

Excision and incision wound models were used to evaluate the wound healing activity on Wistar albino rats by applying the topical application of a prepared ointment. The wound healing potential was assessed by measuring the rate of the epithelization period, wound contraction, wound breaking strength, and histopathological parameters reference with povidone iodine ointment as standard. Higher rate of wound contraction (****P<0.0001), decrease in the period of epithelization (**P<0.01) higher wound breaking strength (****P<0.0001), and favorable histopathological changes were observed with the ointment containing 5% and 10% hydro-ethanolic extract of leaves. The data of this study indicated that hydro-ethanolic Vernonia amygdalina extract of leaves exhibited potent wound healing effects thus the study can be extended in future for the study of phytoconstituents which are giving the wound healing effect.