Efficacy of Polyherbal Formulation (<i>Phalatrikadi Vati</i>) in the Management of Type 2 Diabetes Mellitus through Metabolic Correction – A Clinical Study

Abstract

Background: Diabetes mellitus is a prevalent metabolic disorder worldwide; its incidents have grown notably in recent years. Over the last 50 years, lifestyle changes have led to a dramatic increase in the prevalence of type 2 diabetes around the world. India has been projected as the diabetic capital of the world. Diabetes and its complications pose a major threat to future public health resources throughout the world and are the major cause of blindness, kidney failure, heart attacks, stroke, and lower limb amputation. In the southern part of India, the mortality rate due to diabetes mellitus is in fifth rank amongst the ten vital causes of death. Despite recent advances in knowledge, preventing and controlling diabetes remain a major challenge. So the present study has focused on the disease pathogenesis and its regulation through Polyherbal formulation (Phalatrikadi Vati). Objectives: To determine the efficacy of Polyherbal formulation in reducing the subjective complaints in Type 2 Diabetes Mellitus by metabolic corrections and thereby controlling the blood glucose level in the body. Methods: A single arm open labeled trial with 1 month in duration. Participants: 25 patients of Diabetes Mellitus Type 2 with diagnosed, high fasting blood sugar and postprandial blood sugar levels. 500mg tablet was given in twice a day after food. Results: A total of 30 patients enrolled in the study and 25 patients completed the treatment. Significant relief of 68% in polyuria, 56% in urine turbidity, 84% in polyphagia, and 76% in polydipsia seen. There was a highly significant reduction in FBS with a mean difference of 31.84 mg and PPBS with a mean difference of 63.92 mg. Conclusion: The polyherbal formulation is a safe intervention and can be expected to reduce the symptoms of Type 2 Diabetes Mellitus and blood sugar levels. Future studies with larger sample sizes, longer duration of intervention and follow up needed for more accurate and reliable results.