Study on Formulation, Standardization of Herbal Suspension Containing <i>Musa granatum</i> and its Efficacy against Carrageenan Induced Prostatitis in Rodent Model

Abstract

Prostatis prevalence more in aged males and amidst disputes of severe therapeutic measures, both physicians and patients resort to alternative and non-traditional measures. The aim of this study is to investigate the effect of Musa paradisiaca (lyophilized juice) and Punica granatum (peel powder) suspension by carrageenan-induced method for prostatitis in Sprague Dawley rats. Suspension of Musa paradisiaca (lyophilized juice) and Punica granatum (peel powder) were prepared in equal proportion with high dose (400 mg/kg) and low dose (200 mg/kg) after carrageenan induction for one week. The body weight variation, urine volume analysis, white blood cell count in blood, net weight of the prostate gland and histopathological analysis were the parameters assessed. Punica granatum shows a significant increase in body weight, Prostate gland weight and white blood cell count and a decrease in urine volume in the prostatitis-induced control group animals. In Musa paradisiaca, a decrease in body weight, an increase in the prostate gland, white blood cell count and weight in urine volume was observed. The histopathological report evidence that the presence of leukocytes infiltration, papillary fronds were present and an increase in epithelial height was observed in the carrageenan-induced control group. It has been concluded that the low dose suspension of Musa granatum in 200 mg/kg has given a significantly better amelioration effect than compared to other intervention groups.