<i>In Silico</i> Computational Analysis of <i>Citrus aurantium</i> of <i>Thurunji manapagu</i> in Inhibiting the Receptor Target of Angiotensin-converting Enzyme Against <i>Uratha Pitha Vatham</i> (Hypertension)

Abstract

Citrus aurantium (Thurunji) is a tree cultivated in various parts of the world. The fruit pulp is used to make juices, marmalade and pickles. It is commonly used by tribes to treat digestive disorders, constipation, heaviness in the chest, prolapse of the uterus, anorexia, chest pain, cold, and cough. In the Siddha system of medicine, Citrus aurantium fruit pulp is used to prepare a formulation, syrup in consistency named Thurunji manapaagu indicated for diseases due to deranged pitha humor. According to the Siddha system of medicine Hypertension termed Uratha Pitha Vatham is an ailment that occurs due to an elevated pitham. Considering the facts an attempt of in silico docking study was done with the selected phytochemicals such as Linalool, Apigenin, Ichangin, Kaempferol, Luteolin, Limonin, Limonene, Myrcene, Diosmetin and Tangeretin of Citrus aurantium against Angiotensin Converting Enzyme (ACE) and the results are detailed in this article.