Exploring the Anti-obesity Properties of Corn Silk Extract (CornFit®) in C57BL/6 Mice Induced with Obesity via a High-Fat Diet

Abstract

Objective: The impact of CornFit®, an extract derived from corn silk was assessed on obesity-induced mice subjected to a High-Fat Diet (HFD). Methods: C57BL/6 mice were assigned to seven groups: normal control, HFD control, reference standard and four CornFit® dosage groups. Body weight, food intake, fat mass and metabolic parameters were assessed throughout the study. Biochemical markers, gene expression in liver tissue and histopathological analysis were also performed. Results: Supplementation with CornFit® notably decreased body weight gain, fat mass and enhanced lipid profile compared to the HFD group. It also decreased pro-inflammatory markers and insulin levels while increasing adiponectin and leptin, indicating anti-inflammatory and metabolic benefits. RT-PCR analysis revealed downregulation of lipogenic genes and upregulation of genes involved in fatty acid metabolism and energy expenditure. Liver function tests and organ weights improved in treated groups. Conclusion: CornFit® demonstrates promising anti-obesity potential by reducing fat accumulation, improving metabolic health and modulating related gene expression.