Author:
Gaikwad Chetan,Khune Ajit,Mahadik Sanjay,Balwir Dhiraj
Abstract
Introduction: Hypertension is one of the most common medical disorders during pregnancy, affecting 6-8% of all pregnancies. Around 16-25% of 1st pregnancy &12-15% of subsequent pregnancies8. Ocular fundus changes are found in 40% to 100% of pregnant women with raised blood pressure, whose severity correlates with pre-eclampsia or eclampsia. In hypertensive disorders in pregnancy, ophthalmic manifestations include conjunctival vasculopathy, hypertensive retinopathy, exudative retinal detachment, hypertensive choroidopathy. The retina is involved due to the basic pathology of vasospasm and increased capillary permeability, the consequences of vascular endothelial dysfunction. Rare complications were reversible cortical blindness, and extra-ocular muscle palsy have been documented. Methodology: The present study was conducted in the Outpatient Department (OPD) of Ophthalmology at Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik , Maharashtra. All the 182 cases included in this study underwent indirect ophthalmoscopy during the study period of 2 years (August 2018 to December 2020). Patients were collected from ANC clinic of department of obstetrics and Gynaecology OPD. Results: Prevalence of abnormal fundus findings was 10.1% in grade I hypertension while it was 100% in cases with grade II and III hypertension. A significant association was observed between severity of hypertension and abnormal fundus findings (p<0.01). Prevalence of abnormal fundus findings was 0% among cases with no proteinuria while it was 85.7% in cases with grade 1+ proteinuria. All the cases with grade 2+ or more proteinuria had abnormal fundus findings. A significant association was observed between severity of proteinuria and abnormal fundus findings (p<0.01). No association was observed between laboratory parameters like haemoglobin, uric acid and blood urea nitrogen levels with abnormal fundus findings (p>0.05). Conclusion: As these vascular changes in the retina usually correlate with the severity of the systemic hypertension, the eyes can truly be considered a mirror to the otherwise elusive vascular changes occurring elsewhere in the body. It thus stands to reason that observing the retinal changes holds the ability to prognosticate and also determine the severity of the disease. Fundoscopy is an essential investigation that needs to be done in all cases of hypertensive disorders of pregnancy with special emphasis in younger and primigravida women.
Publisher
Informatics Publishing Limited
Reference24 articles.
1. Erem C, Hacihasanoglu A, Kocak M, Deger O, Topbas M. Prevalence of prehypertension and hypertension and associated risk factors among Turkish adults: Trabzon Hypertension Study. J. Public Health. 1 Mar 2009; 31(1):47–58. https://doi.org/10.1093/pubmed/fdn078
2. Ahmed A, Rahman M, Hasan R, Shima SA, Faruquee MH, Islam T, Haque SE. Hypertension and associated risk factors in some selected rural areas of Bangladesh. Int J Res Med Sci. Jul 2014; 2(3):925. https://doi.org/10.5455/23206012.ijrms20140816
3. Mishra CP, Kumar S. Risk factors of hypertension in a rural area of Varanasi. Indian Journal of Preventive and Social Medicine. Jan 2011; 42(1):101–11.
4. Abebe SM, Berhane Y, Worku A, Getachew A. Prevalence and associated factors of hypertension: a crossectional community-based study in Northwest Ethiopia. PloS one. 24 Apr 2015; 10(4):e0125210. https://doi.org/10.1371/journal.pone.0125210
5. Mendis S, Armstrong T, Bettcher D, Branca F, Lauer J, Mace C. World Health Organisation; 2010. Global status report on non-communicable diseases 2010. World Health Organization http://www.who. int/nmh/publications/ncd_ report2010/en. 2014.