Histopathological and Immunohistochemical Analysis of Ruptured Tubal Ectopic Pregnancy

Abstract

Ectopic Pregnancy (EP) is reported to be causative of high incidence of maternal death and morbidity. It must be diagnosed during the first trimester immediately after symptoms of severe bleeding, abdominal pain, and cramping. Ultrasonography is the only possible detection method to confirm EP. Patients are at greater risk of EP due to inefficient early detection methods. An early detection of the EP based on cellular markers would possibly improve the diagnosis and clinical management. Therefore, an attempt was made to study the histoarchitecture of, and to identify the biomarkers in, the fallopian tube during rupture of ectopic pregnancy. Histological analysis revealed the formation of hematosalpinx and hydrosalpinx in the fallopian tube. Further, immunohistochemical study of the fallopian tissue of EP patients showed remarkable evidence of protein markers such as Bcl2 and desmin which may be considered as potential cellular markers for the detection of EP.