Combustion Synthesis of Nano CeO₂ and its Application as a Catalytic Agent in Peptidomimetics

Abstract

An eco-friendly cerium oxide nanoparticle was prepared through a solution combustion system with a novel fuel plant seed source Albizzia richardiana. The synthetic technique involves the Albizzia richardiana plant seeds as a fuel and cerium nitrate as an oxidizer (basis of cerium) was added in stoichiometric quantity in a well washed silica crucible and stirred for several minutes until persistent uniform solution was made. Then the mixture was kept in a heat up heating chamber at 500 °C. After dehydration and decomposition of homogeneous solution, the obtained CeO2 nanoparticles were thoroughly characterized using FT-IR, XRD and SEM morphological analysis. The synthesized nano CeO2 was a better catalytic agent for the production of Nα-Fmoc/Cbz-keto-1,2,3-triazole equivalents through the three-constituent reaction between amino acyl chloride equivalents of Fmoc/Cbz-protected amino acids, phenyl acetylene and sodium azide. Keto-1,2,3-triazoles were set upon by refluxing amino acyl chlorides with NaN3 and phenyl acetylene in presence of CeO2 nano particles in methanol. After a simple workup, the desired products obtained were fully categorized by FTIR, HRMS, proton and 13C NMR techniques.