Chronic Exposure to Heavy Metals Declines Sperm Quality and Damages Tissue Architecture

Author:

De Chaudhuri Sujata

Abstract

This study aimed to assess the toxic effects of heavy metals in adult male rats after chronic exposure in early life stages. Juvenile male Wistar rats were kept in constant supply of drinking water having heavy metal salts such as Sodium Arsenite, Cadmium Chloride and Lead Acetate of dose 100 times higher than Maximum Contamination Limit (MCL; laid done by US EPA, 2009) for 3 months along with control rats with a supply of heavy metal free water. The result showed decreased sperm count and increase in abnormal sperm in all treated cases. Histopathology showed that testes and liver tissues of treated rats were severely damaged. Thus, this study showed that chronic exposure to heavy metals such as Arsenic, Cadmium and Lead in juvenile period may result in reduced reproductive capacity at later stage of life.

Publisher

Informatics Publishing Limited

Subject

Public Health, Environmental and Occupational Health,Pollution,Ecology

Reference13 articles.

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3. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for lead 2007 [displayed 3 January 2012] Available at http://www.atsdr.cdc.gov/toxprofiles/tp13.pdf

4. Siu ER, Mruk DD, Porto CS, Cheng CY. Cadmium-induced Testicular Injury Toxicol Appl Pharmacol. 2009 Feb 21; 238(3):240–9.

5. Sarkar M, Chaudhuri G, Chattopadhayay A, Biswas NM. Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats. Asian J Androl. 2003 Mar; 5:27–31.

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