Bioinformatics and Experimental Databases as Significant Research Paraphernalia in Oral Cancer - A Narrative Review

Abstract

Among head and neck squamous cell carcinomas the incidence of Oral Squamous Cell Carcinoma (OSCC) is highest (80%). Bioinformatics provides a wide-ranging outlook to understand the significant genes, proteins, pathways, and molecular mechanisms fundamental to oral carcinogenesis. It is a promising branch in the field of biomedical research with emerging popularity in the field of dental research too, targeting immune-mediated, developmental, genetic, and malignant diseases. High-throughput experimental technologies have created large and complex genomic data, which has revolutionized genomic research. Advanced technologies including microarray, next-generation sequencing, and bioinformatics together play a decisive role in unraveling the molecular mechanism in the process of Head and Neck cancer. This article is an attempt to give an overview of the significant role of bioinformatics in the field of genomic research.