Immunological control of the effectiveness of correction of subcompensated intestinal dysbacteriosis in cats

Abstract

Relevance. Intestinal dysbacteriosis should be considered as a clinical and laboratory syndrome that occurs in a number of diseases and clinical situations, characterized in addition to changes in the qualitative and quantitative composition of the microbiota, metabolic and immune disorders, what can be accompanied by severe clinical manifestations in its unfavorable course. Therefore, the choice of the most optimal therapeutic regimen, as well as the immunological evaluation of its effectiveness in correcting the subcompensated degree of intestinal dysbacteriosis in cats is an important area of scientific research in veterinary gastroenterology.Methods. The efficacy of pharmacotherapy in cats with subcompensated intestinal dysbacteriosis (n = 16) was evaluated. The diagnosis of suspected intestinal dysbacteriosis was made in a complex manner, taking into account the data of the anamnesis, clinical examination and microbiological studies. The severity of intestinal dysbacteriosis (grade 1 — compensated; grade 2 — subcompensated; grade 3 — decompensated) was assessed on the basis of clinical and laboratory studies. Cats with subcompensated intestinal dysbacteriosis (grade 2) were randomly divided into three experimental groups: В1 (n = 5); В2 (n = 5) and В3 (n = 6). The dynamics of individual immunological parameters of the blood of cats (indicators of cellular and humoral links, pro-inflammatory cytokines) with dysbacteriosis of the 2nd degree of severity during their therapy (before correction, on days 7 and 14) is shown.Results. With subcompensated intestinal dysbacteriosis, the administration of the probiotic «Lactobifadol» in combination with the prebiotic «Vetelact» and the immunomodulator «Azoksivet» shows the greatest therapeutic effect, which leads to an overall clinical improvement within 5.50 days. At the same time, the normalization of appetite, unpleasant odor from the oral cavity and the nature of fecal matter occurs in cats of group B3 by 3.1; 1.47 and 1.24 days respectively earlier, when in animals that received only «Lactobifadol».