Bisphosphonate-Related Osteonecrosis of the Jaws Treated with Platelet-Rich Plasma: Preliminary Results from a Case Series

Abstract

OBJECTIVE: The aim of this case series was to evaluate the effectiveness of a new platelet-rich plasma preparation B.P.F.C. BIO-PLASMA® RICH IN PURE GROWTH FACTORS®, FOR OBTAINING BIOLOGICALLY GUIDED REGENERATION (Bioplasma®, Dr. Raffaello Viganò, Varese Italy), for the treatment of Bisphosphonate-related osteonecrosis of the jaws (BRONJ). MATERIALS AND METHODS: Thirty-five patients (15 men, 20 women; aged between 51-78 years; mean age 64 years) were enrolled in this study and treated with a regenerative surgical procedure using a platelet-rich plasma preparation. RESULTS: All patients were treated successfully with regard to healing parameters. CONCLUSION: This new preparation B.P.F.C. BIO-PLASMA® RICH IN PURE GROWTH FACTORS®, seems able to restore an intact mucosa in BRONJ-affected patients. Further studies are necessary to validate these results with a larger sample size and a longer follow-up time.