Developing the theory of Toxic Chemotherapeutic Nutrition for Cancer Cells: Glucosodiene Polymer Structure, Safety, Efficacy, and Human Outcomes in Targeting Tumors via Glucose Mutation

Author:

Akl MaherORCID,Ahmed AmrORCID

Abstract

Cancer is a complex genetic disease characterized by aberrant cellular behaviors, including uncontrolled growth, invasion, and metastasis. The development of personalized treatment strategies based on genomic profiling has led to improved outcomes. Recent scientific endeavors have focused on targeting cancer through metabolic approaches, capitalizing on the altered metabolic pathways in cancer cells. Glucosodiene polymer, a newly derived compound from glucose, has shown promising results in inhibiting glucose metabolism and modifying the tumor's microenvironment acidity. The Maher Akl Theory "Glucose Mutation" proposes a strategic approach to target cancerous tumors by inhibiting glucose metabolism and altering the tumor's microenvironment acidity using glucose isomer polymers. The goal is to disrupt the metabolic activity of the tumor and potentially modify and control the disease. This manuscript provides an overview of the metabolic vulnerabilities of cancer cells, evaluates the synthesis and chemical structure of glucosodiene, documents its safety, and explores its potential as a targeted therapy for cancer treatment. Additionally, a subset of successful clinical trials is presented, focusing on a case of successful treatment of triple-negative breast cancer (TNBC) with glucosodiene. The potential mechanisms of action of glucosodiene in cancer, including its impact on glucose metabolism, modulation of signaling pathways, and immune-enhancing effects, are discussed.

Publisher

Qeios Ltd

Reference22 articles.

1. Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell, 144(5), 646-674. DOI: 10.1016/j.cell.2011.02.013.

2. Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz Jr, L. A., & Kinzler, K. W. (2013). Cancer genome landscapes. Science, 339(6127), 1546-1558.DOI: 10.1126/science.1235122.

3. Siegel, R. L., Miller, K. D., & Jemal, A. (2020). Cancer statistics, 2020. CA: A Cancer Journal for Clinicians, 70(1), 7-30. DOI: 10.3322/caac.21590.

4. Kumar AR, Devan AR, Nair B, Vinod BS, Nath LR. Harnessing the immune system against cancer: current immunotherapy approaches and therapeutic targets. Mol Biol Rep. 2021 Dec;48(12):8075-8095. doi: 10.1007/s11033-021-06752-9. Epub 2021 Oct 20. PMID: 34671902; PMCID: PMC8605995.

5. Roychowdhury, S., & Chinnaiyan, A. M. (2016). Translating genomics for precision cancer medicine. Annual Review of Genomics and Human Genetics, 17(1), 87-113.DOI: 10.1146/annurev-genom-083115-022339. Liberti MV, Locasale JW. The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci. 2016 Mar;41(3):211-218. doi: 10.1016/j.tibs.2015.12.001. Epub 2016 Jan 5. Erratum in: Trends Biochem Sci. 2016 Mar;41(3):287. Erratum in: Trends Biochem Sci. 2016 Mar;41(3):287. PMID: 26778478; PMCID: PMC4783224.

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