Abstract
Pathophysiological mechanisms and allergies implicated in Obstructive Sleep Apnoea-asthma associated are unclear. Apnoea hypopnea index alone does not seem sufficient to correctly guide for adequate treatment without identification of the specific profile of each patient. Children suffering from allergies and Sleep-Disordered-breathing-asthma associated are treated with the same recommendations as those suffering from the obstructive type of Sleep Apnoea. It remains uncertain whether allergies pre-exist, predisposing to obstructive sleep apnea.
Obesity is considered a risk factor for OSA. Nevertheless, children with Obstructive Sleep Apnoea increase their Body Mass Index despite being treated adequately for sleep apnoea and following adapted weight interventions.
We aimed to study the Respiratory Polygraphy/Polysomnography profile of children suffering Obstructive Sleep Apnoea-asthma associated and the influence of allergies and Asthma Treatment/Eviction Diet upon Apnoea Hypopnea Index/Respiratory Effort/Body Mass Index to diagnose, treat and prevent pediatric Obstructive Sleep Apnoea-asthma and obesity associated early and accurately.
Our study had a cross-sectional/case control/diagnostic part and a cohort part to evaluate the treatments’ and allergies’ effect on Polygraphy/Polysomnography parameters (Apnoea Hypopnea Index, Respiratory Effort, Body Mass Index, Respiratory Distress Index, Sleep Fragmentation, Sleep Fragmentation Ventilatory Origin, Oxygen Desaturation Index).
We identified that asthma treatment, specific eviction diet, and the co-existence of non-IgE-mediated and respiratory allergies, influence the Apnoea Hypopnea Index, Respiratory Effort during sleep and the Body Mass Index.
Consideration of asthma treatment, allergies, and eviction diet upon interpretation of polygraphy/polysomnography parameters could ameliorate the diagnosis and treatment of Obstructive Sleep Apnoea-asthma associated and possibly avoid, upon their origin, asthma, and obesity.