Abstract
Pathophysiological mechanisms and allergies in Obstructive Sleep Apnoea-asthma associated are unclear. Apnoea hypopnea Index alone does not seem sufficient to correctly guide for adequate treatment without identification of the specific profile of each patient. Obstructive Sleep Apnoea correlates to obesity; however, links between obesity, allergy, and Obstructive Sleep Apnoea remain unexplored. Obese allergic children with Obstructive Sleep Apnoea increase their Body Mass Index despite adequate weight interventions.
We aimed to study the Respiratory Polygraphy/Polysomnography profile of children suffering Obstructive Sleep Apnoea-asthma associated and the influence of allergies and Asthma Treatment/Eviction Diet upon Apnoea Hypopnea Index/Respiratory Effort/Body Mass Index to diagnose, treat and prevent pediatric Obstructive Sleep Apnoea-asthma associated and related obesity early and accurately.
We effectuated a cross-sectional/case controls diagnostic cohort. We used Receiver Operating Characteristic curves, General Linear Models, regression, and path analysis to evaluate the effect of treatments and allergies on Apnoea Hypopnea Index, Respiratory Effort, Body Mass Index and Polygraphy/Polysomnography parameters such as Respiratory Distress Index, Sleep Fragmentation, Sleep Fragmentation Ventilatory Origin, Oxygen Desaturation Index.
We identified that asthma treatment and specific allergen eviction, along with the co-existence of non-IgE-mediated and respiratory allergies, influence the Apnoea Hypopnea Index, Respiratory Effort during sleep and the Body Mass Index.
Allergies, asthma treatment and allergen eviction are implicated in the pathophysiological mechanisms of Obstructive Sleep Apnoea and obesity. Consideration of asthma treatment, allergies, and allergen eviction upon interpretation of polygraphy/polysomnography parameters could ameliorate the diagnosis and treatment of Obstructive Sleep Apnoea-asthma associated and possibly avoid, upon their origin, asthma, and obesity.