Abstract
When a new infectious disease emerges, memory cells from previous exposure to a related, but different, micro-organism may become activated. This phenomenon has been termed the original antigenic sin. When the induced antibodies against the related micro-organism would be not functional, the original antigenic sin would impair the effectivity of the primary response. Otherwise, the sin would turn out to be a virtue because the memory response would contribute to the elimination of the emerging infectious disease.
Reference26 articles.
1. Bonaventure S. The life of Christ (translated and edited by WH Hutchings). London: Rivingtons, 1881. https://catalog.hathitrust.org/Record/009034055 (cited 2023, January 22)
2. Hoogstede L, Spronk R, Ilsink M, Koldeweij J, Erdmann RG, Klein Gotink R, Nap H, Veldhuizen D. Hieronymus Bosch, painter and draughtsman. Technical studies, volume 2. Tale University Press, 2016, 496 pp.
3. Francis T, Salk JE, Quilligan JJ. Experience with Vaccination Against Influenza in the Spring of 1947: A Preliminary Report. Am J Public Health Nations Health. 1947;37:1013-6.
4. Francis, T. On the Doctrine of Original Antigenic Sin. Proc Am Phil Soc, 1960; 104: 572-8.
5. Rothman AL. Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms. Nat Rev Immunol 2011; 11: 532-43.