Burden and Predictors of Diabetic Nephropathy in an Adult With Diabetes Mellitus Patients on Follow up at Ambo University Referral Hospital Central Ethiopia

Abstract

BACKGROUND: Despite the growing evidence of Diabetic Nephropathy in adult patients with long-standing diabetes in sub-Saharan Africa, data on its burden and correlates in adult African patients with diabetes are limited. We, therefore, undertook this study to determine the burden and predictors of Diabetic Nephropathy n an adult population with diabetes in Hospital. OBJECTIVE: We, therefore, undertook this study to determine the burden and predictors of Diabetic Nephropathy n an adult population with diabetes in Hospital. METHODS: A Hospital-based cross-sectional study was conducted from June to August, 2023 and a systematic random sampling method used to recruit participants. A total of 4,300 diabetics are under observation. The interviewer used structured questionnaires to gather data from the study subjects. For data entry and analysis, Epi Data version 3.1.1 and SPSS version 25 were used. Multivariable logistic regression analysis was done after descriptive statistics. 95% confidence intervals (CI) and crude and adjusted odds ratios were presented. RESULTS: Diabetic Nephropathy (DN) was documented in population was 24.9% from the 369 participants (95%; CI 23.37– 26.43) participants among the study). Male sex [AOR = 2.215; 95% CI: 1.34, 3.45, p = 0.002], physically inactive [AOR = 1.983; 95% CI: 1.05, 3.70), P = 0.034], dyslipidaemia [AOR: 1.98, CI: 1.009, 3.5), P = 0.024] and poor controlled glycemia [AOR= 2.70; 1.40, 5.2), P = 0.003] were significant determinants for the development of Diabetic Nephropathy. Therefore, it is advised that healthcare professionals pay close attention to patients who have recognized related factors during follow-up in order to reduce the likelihood of DN. CONCLUSION: Among DM patients, sex, physical inactivity, dyslipidaemia, and poor glycemic control were discovered to be the predictors of diabetic nephropathy. By enhancing programs for health information, education, and promotion, diabetes management should be better equipped to achieve glycaemic control and prevent diabetic nephropathy. Male sex, sedentary lifestyles, dyslipidemia, and patients with poor glycemic control need to receive more attention.