[Hypothesis] The protective role of Testosterone in COVID-19-Reference-Cited by-同舟云学术

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[Hypothesis] The protective role of Testosterone in COVID-19

Published:2023-02-23 Issue: Volume: Page:
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Author:

Knack Rafael^ORCID,Rizzo Luiz Vicente,Bertero Eduardo B.,Hanada Taliê Z. B.,Knack Renata S.,Afonso Gil L.,Omena Thiago,Mayr Kamilla

Abstract

In this manuscript, we hypothesize that testosterone may play a protective role against the severity of SARS-CoV-2 infection through immunomodulatory mechanisms with anti-inflammatory effects supported by the action of testosterone.

Publisher

Qeios Ltd

Link

https://www.qeios.com/read/EB4970/pdf

Reference12 articles.

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2. Singh N, Bharara Singh A. S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study. Translational Oncology. 2020;13(10):100814.

3. Malkin CJ, Pugh PJ, Jones RD, Jones TH, Channer KS. Testosterone as a protective factor against atherosclerosis--immunomodulation and influence upon plaque development and stability. The Journal of Endocrinology. 2003 Sep;178(3):373-380. DOI: 10.1677/joe.0.1780373

4. Ramos AM, Pellanda LC, Gus I et al. Inflammatory markers of cardiovascular disease in the elderly. Arq Bras Cardiol. 2009;92:221-228, 227-234.

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