Cannabidiol Modulation of Nicotine-Induced Toxicity: Assessing Effects on Behavior, Brain-Derived Neu-Rotrophic Factor, and Oxidative Stress C57BL/6 Mice

Author:

Mesiakaris KonstantinosORCID,Atsopardi Korina,Lagoumintzis George,Margarity Marigoula,Poulas KonstantinosORCID

Abstract

High doses of nicotine in rodents are known to induce anxiety, dysregulate brain-derived neu-rotrophic factor (BDNF) levels, contribute to oxidative stress, and promote the secretion of cytokines. Conversely, at lower doses, nicotine exhibits anxiolytic effects. The endocannabinoids and nicotine modu-late several central nervous system processes via their specific receptors, impacting locomotion, anxiety, memory, nociception, and reward. Cannabidiol (CBD), a non-psychoactive active ingredient of Cannabis sativa L., has garnered scientific attention primarily due to its recognized effects, including anxiolytic, an-tioxidant, and anti-inflammatory properties. This work aims to explore the potential anxiety-reducing properties of CBD in a well-established experimental mouse model of anxiety-like behavior induced by high doses of nicotine. In this context, the open field behavioral test was specially conducted to assess CBD’s effects on anxiety-like behavior and locomotion. Brain neuronal plasticity, modulated by brain-derived neurotrophic factor (BDNF), along with a diverse array of blood’s metabolic markers, was examined as a means of evaluating systemic toxicity under various treatments. Finally, oxidative stress was evaluated through the measurement of GSH, SOD, and MDA, while pro-inflammatory cytokine assessments were conducted to evaluate redox status and immune system function. Our findings indicate that CBD holds promise in alleviating high-dose nicotine-induced anxiety-like behaviors by targeting specific liver en-zymes, maintaining tissue’s systemic toxicity (i.e., renal, kidney, and pancreatic), balancing redox reactions (SOD, GSH, and MDA), promoting secretion of pro-inflammatory cytokines (TNF-alpha and IL-6), and mitigating changes in BDNF protein levels.

Publisher

Qeios Ltd

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3