Inhibiting Efflux Pumps and Resistance Mechanisms: A Mini Review
Author:
Abusaiba Thualfakar Hayder HasanORCID, Hussein Ali Abdul, Almahbob Taghreed F.
Abstract
Efflux pumps play a significant role in the development and spread of antibiotic resistance among bacteria. These specialized membrane proteins actively pump out various antibiotics and other toxic compounds, allowing bacteria to survive and thrive in the presence of these substances. Understanding the mechanisms by which efflux pumps contribute to antibiotic resistance is crucial for devising effective strategies to combat this global health threat. This article delves into the intricacies of efflux pump-mediated resistance, exploring the types and functions of efflux pumps, their role in antibiotic resistance, and the strategies employed to inhibit their activity. Additionally, it examines the challenges and future prospects in developing efflux pump inhibitors, highlighting case studies that showcase both successes and failures in this field. By shedding light on the inhibitory potential of efflux pumps, this article aims to contribute to the broader efforts in combating antibiotic resistance.
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