Individual’s Adaptive Processes: Rephrasing in Terms of Inflammation

Abstract

Inflammation, one among the evolutionary driving forces, is now acknowledged under two subheadings, depending on whether the individual immune system has been educated under the pressure of nature’s physiologic stressors, or under man-made artificial drifts. In the former case, the reaction is demarcated and self-resolving, at the expense of possible host death. In the latter, the evolution is chronic, sparing subject’s life at the expense of chronic multi-organ inflammatory disease. There is now evidence that this disorder is reaching epidemics-like proportions. Adaptation with immunologic down grading and tolerance may be the way to individual’s survival. We analyze the literature that in our own arbitrary opinion supports this view, including a final proof-of concept based on human volunteer data elaboration.