Abstract
BACKGROUND: With antibiotic resistance posing a growing threat to global health, the prudent use of antibiotics like meropenem is imperative. However, empirical prescribing practices and inadequate adherence to guidelines contribute to challenges in meropenem utilization. This study aims to comprehensively assess prescribing patterns, adherence to guidelines, and patient education practices in a tertiary care hospital in Pakistan.
METHODS: A cross-sectional study was conducted over six months, enrolling 100 patients. Data collection included variables such as age, gender, hospital stay duration, indication for meropenem prescription, dosage regimen, basis of prescription, treatment duration, and patient education. Statistical analysis was performed using IBM SPSS version 26.
RESULTS: Empirical prescribing was common, with an initial diagnosis accuracy rate of 64%. Disparities were noted in aligning culture sensitivity with meropenem use, with only 36% of cases following culture results. Regarding treatment duration, an alarming 86% of cases had incorrect durations. Comparative analyses highlighted areas for prescription protocol and clinical outcome improvement. For instance, 96% of cases had the correct initial meropenem dosage. Despite meticulous monitoring, deficiencies persisted in patient education and antibiotic stewardship.
CONCLUSION: The study underscores the urgent need for standardized guidelines, enhanced diagnostics, and educational initiatives to mitigate antibiotic resistance emergence. Addressing these challenges is crucial for safeguarding antibiotic efficacy and public health.