PREVENTIVE EFFECTS OF CITRULLUS COLOCYNTHIS. L PLANT EXTRACT ON DELTAMETHRIN PESTICIDE INDUCED PNEUMOTOXICITY IN WISTER RATS

Abstract

Pesticides are chemicals used to fight agricultural pests. Their use causes extensive damage to both humans and animals, resulting in diseases mainly affecting the respiratory and digestive systems. Through this study, we evaluated the pneumotoxicity caused by a deltamethrin (DM) insecticide at a dose of 0.64mg.kg-1.day-1. We also evaluated the preventive and curative effect of the medicinal plant "citrullus colocynthis. L" antagonist of this toxicity at a dose of 150mg.kg-1.day-1. We carried out the experimental application on Wister rats as an animal model of exhalation. Several experiments were carried out on the activity of enzymes and vital indicators. This study revealed a decrease in the concentration of the protein accompanied by a decrease in the means of development of the body [25±0.23]. Then, our study showed that DM has an oxidative effect, resulting in a decrease in the level of GSH [0.05 ±0.00] and the enzymatic activity of GPx [0.34±0.05]. In addition to an increase in the level of MDA [4.90±0.72] and the enzymatic activity of GST [0.84±0.11]. In addition, the histological study carried out on a fragment of lung of rats treated with this pesticide showed changes in the histological structure of the lungs resulting in vascular congestion, infiltration of inflammatory cells, thickening of the walls of blood vessels, as we do. Observed intra-alveolar hemorrhages and hyperplasia of the alveolar lining. On the other hand, we have confirmed the preventive effect of the citrullus colocynthis. L after treatment with this pesticide, which has an anti-oxidant activity, which can reduce the intensity of the oxidative stress resulting from deltamethrin and its effectiveness. In the treatment of lung, tissue effected by this pesticide and it is stored in its natural state.