Affiliation:
1. State Scientific Institution "Institute of Genetics and Cytology of the National Academy of Sciences of Belarus"
2. Belarusian State Medical University
Abstract
Epigenetic changes are currently considered to be the main determinants of the psycho-emotional state of a person. In
this work, we studied the level of methylation of 24 target CpG sites in the DNA of three psychoemotionally different groups of Belarusian population representatives: the control group of conditionally healthy volunteers, patients of the Republican Scientific and Practical Center for Mental Health with personality disorders, and representatives of the special forces of the Ministry of Internal Affairs of the Belarus Republic. Statistically significant differences between the groups were found for 11 CpG sites located in the promoter regions of eight genes of the brain neurotransmitter systems responsible for the psycho-emotional status of a person — FKPB, COMT, CACNA1C, HTR2A, OXTR, NR3C1, CRH, and SKA2. The most significant differences in the level of methylation were established for the target sites of
genes encoding serotonin and oxytocin receptors, HTR2A and OXTR, the analysis of which can be of great practical importance for medicine and forensics.
Publisher
National Academy of Sciences of Belarus
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