IDENTIFICATION OF THE GENETIC DEFECT OF DEVELOPMENTAL DUPLICATION (DD) IN THE BELARUSIAN POPULATION OF ABERDEEN ANGUS CATTLE-Reference-Cited by-同舟云学术

IDENTIFICATION OF THE GENETIC DEFECT OF DEVELOPMENTAL DUPLICATION (DD) IN THE BELARUSIAN POPULATION OF ABERDEEN ANGUS CATTLE

Published:2022-11-12 Issue: Volume:33 Page:102-108
ISSN:1999-9127
Container-title:Молекулярная и прикладная генетика
language:
Short-container-title:Молекулярная и прикладная генетика

Author:

Ramanishka E. L.¹,Mikhailova M. E.¹,Kireyeva A. I.¹,Sheyko R. I.¹

Affiliation:

1. State Scientific Institution “Institute of Genetics and Cytology of the National Academy of Sciences of Belarus”

Abstract

Developmental duplication (DD) is a monogenic autosomal recessive disease with incomplete penetrance and variable expressivity of Aberdeen Angus cattle, resulting in calves with twice the number of various organs and limbs of the animal. According to the literature, the frequency of mutations that cause developmental duplications in Aberdeen is high (above 20%). Single nucleotide polymorphism (SNP) g.34618072T > C in the NHLRC2 gene, which causes developmental duplication, was studied by PCR-RFLP. We screened a sample from the Belarusian population of Aberdeen-Angus cattle (n = 170 heads), which did not reveal animals carrying the mutant allele (DDC) both among the studied cows and among bulls.

Publisher

National Academy of Sciences of Belarus

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