CERTAIN ASPECTS OF GENETIC PREPOSITION TO THE DEVELOPMENT OF COMBINED AUTOIMMUNE DISEASES IN CHILDREN WITH TYPE 1 DIABETES MELLITUS-Reference-Cited by-同舟云学术

CERTAIN ASPECTS OF GENETIC PREPOSITION TO THE DEVELOPMENT OF COMBINED AUTOIMMUNE DISEASES IN CHILDREN WITH TYPE 1 DIABETES MELLITUS

Published:2021-04-12 Issue: Volume:30 Page:5-13
ISSN:1999-9127
Container-title:Молекулярная и прикладная генетика
language:
Short-container-title:Молекулярная и прикладная генетика

Author:

Aksyonova E. A.¹,Solntsava A. V.²,Ivanova A. S.¹,Volkova N. V.³,Sukalo A. V.³,Davydenko O. G.¹

Affiliation:

1. State Scientific Institution “Institute of Genetics and Cytology of the National Academy of Sciences of Belarus”

2. Belarusian Research Center for Pediatric Oncology, Hematology and Immunology

3. Belarusian State Medical University

Abstract

Genotyping of 64 children of the main group with combined with type 1 diabetes mellitus (type 1 diabetes) autoimmune diseases (autoimmune thyroiditis (AIT) and/or celiac disease) and 135 pediatric patients of the comparison group with isolated type 1 diabetes mellitus was performed by predictor gene alleles not related to HLA: CT60 (+6230G>A) (rs3087243), c.49A>G (rs231775) of the cytotoxic T lymphocyte antigen-4 (CTLA4) gene, c.1858C>T (rs2476601) of the tyrosine phosphatase lymphocyte (PTPN22) gene, a microsatellite repeat in exon 5 of the gene of non-canonical histocompatibility class I MICA molecules. In patients with combined AIT type 1 diabetes mellitus, an association was established between the c.49AA genotype (rs231775) and the A allele at the CT60 (+6230G>A) (rs3087243) loci of the CTLA4 gene with the risk of transient antibodies to gliadin. In all groups of patients, the MICA 5.1 STR allele prevailed. The presence of the MICA A5.1/ A5.1 homozygous genotype in patients with type 1 diabetes doubles (OR = 2.13, 95% CI: 1.0003-4.5321, P = 0.0499) the risk of AIT development.

Publisher

National Academy of Sciences of Belarus

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