COMPARATIVE CHARACTERISTICS OF THE GENETIC STRUCTURE OF THE MENINGOKOCCAL POPULATION IN THE REPUBLIC OF BELARUS IN THE PREVACCINAL PERIOD-Reference-Cited by-同舟云学术

COMPARATIVE CHARACTERISTICS OF THE GENETIC STRUCTURE OF THE MENINGOKOCCAL POPULATION IN THE REPUBLIC OF BELARUS IN THE PREVACCINAL PERIOD

Published:2021-04-12 Issue: Volume:30 Page:49-60
ISSN:1999-9127
Container-title:Молекулярная и прикладная генетика
language:
Short-container-title:Молекулярная и прикладная генетика

Author:

Kharkhal H. N.¹,Titov L. P.¹

Affiliation:

1. Republican Research and Practical Center for Epidemiology and Microbiology of the Republic of Belarus

Abstract

Meningococci circulating among the population of the Republic of Belarus during the observed pre-vaccination interepidemic period (2006–2019) is characterized by dynamism. A change in the serogroup structure was noted with a decrease of meningococci serogroup A and non-grouped strains; an increase of meningococci serogroups B and Z. Elimination of MenE and the emergence of MenW were observed. “Belarusian” meningococci are part of 13 known clonal complexes. CC-103 is represented by endemic ST and is associated with MenB and MenW; CC-41/44 evenly included serogroups B and C. CC-11 is responsible for the outbreak of meningococcal infection in 2016-2018 caused by ST-11 MenW. CC-18 was characterized by the proliferation of serogroups B and C. Clonal complexes CC-53, CC-174 and CC-1136 represented by various meningococcal serogroups in the world population were associated in the territory of Belarus with MenB, MenC and MenA respectively. Among the ST CC-103 and CC-41/44 registered in the world, “Belarusian” meningococci are phylogenetically represented as a separate cluster.

Publisher

National Academy of Sciences of Belarus

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