NEOPLASTIC DISEASE OF SMALL ANIMALS AND LATENT TUBERCULOSIS INFECTION

Author:

Lysenko A. P.,Kuchvalski M. V.,Yakobson E. I.,Krasnikova E. L.,Poloz A. I.,Anikevich N. Y.

Abstract

An antigens of tuberculosis mycobacteria (MTB), microgranulomas with acid-fast grains, cell wall deficient (CWD) MTB were found in tumors of small domestic animals. CWD MTB were isolated from tumor in all cases. The isolates did not differ in morphology and antigenic composition, either from each other or from isolates from human tumor cell cultures (Kasumi, Jurkat, Hela), had up to 26 common antigens with typical MTB, were resistant to antibiotics affecting cell wall synthesis. MTB as universal intracellular pathogen with unique filterability and «immortality» can be considered as the most likely etiological agent of oncogenesis based on the hypothesis following: DNA absorption of aging and necrotic normal cells by persistent microorganisms, hybridization of their DNA with host DNA with subsequent expression of the hybrid genome turns normal cells into cancer ones.

Publisher

National Academy of Sciences of Belarus

Reference40 articles.

1. Манкин, З. В. Лимфогрануломатоз / З. В. Манкин. – Л. : Государственное издательство биологической и медицинской литературы, 1938. – 451 с.

2. Warthin, A. S. The Coexistence of Carcinoma and Tuberculosis of the Mammary Gland / A. S. Warthin // The American Journal of the Medical Sciences. – 1899. – Vol. 118, № 1. – P. 25–34.

3. Ewing, J. Neoplastic Diseases / J. Ewing. – Third edition. – Philadelphia and London : W. B. Saunders Co. Ltd., 1928. – 1127 p.

4. Fraenkel, E. Bemerkungen zur Aetiologie der Hodgkinschen Krankheit und der Leukaemia lymphatica / E. Fraenkel, H. Much // Münchener med. Wochеnschr. – 1910. – B. 57. – S. 685.

5. Lichtenstein, A. Pseudoleukämie und Tuberkulose / A. Lichtenstein // Virchows Archiv für pathologische Anatomie und Physiologie und für klinische Medizin. – 1910. – B. 202, № 2. – S. 222–237.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3