Synthesis of novel pyrazole derivatives using organophosphorus, stibine, and arsine reagents and their antitumor activities
Author:
El-Sayed Naglaa F.1, Ewies Ewies F.1, El-Hussieny Marwa1, Boulos Leila S.1, Shalaby ElSayed M.2
Affiliation:
1. Department of Organometallic and Organometalloid Chemistry , National Research Centre, 31-El-Bohouth Street, 12622 Dokki, Giza, A. R. Egypt 2. X-Ray Crystallography Laboratory , Physics Division, National Research Centre, 31-El-Bohouth Street, 12622 Dokki, Giza, A. R. Egypt
Abstract
Abstract
The reactions of 5-azido-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde (azidopyrazole) with several classes of organophosphorus reagents: phosphonium ylides, Wittig-Horner reagents, dialkylphosphonates, trialkylphosphites, tris(dialkylamino)phosphanes, triphenylstibane, triphenylarsane, and Lawesson’s reagent are reported. Structural reasoning for the new products was based on compatible analytical and spectral data. The cytotoxic activity of most of the new products was evaluated against human breast carcinoma cell line (MCF7) and human hepatocellular carcinoma cell line(HepG2). Certain tested compounds showed promising results.
Publisher
Walter de Gruyter GmbH
Subject
General Chemistry
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