Affiliation:
1. Faculty of Chemistry, Department of Organic Chemistry, University of Kashan, Kashan, PO Box 87317-51167, Iran
Abstract
Abstract
The ultrasound-assisted preparation of 2-(1H-tetrazol-5-yl) acrylonitrile derivatives via a one-pot multi-component method is described successfully using ZrP2O7 nanoparticles as a catalyst. Readily available tetrazoles can be transformed into the corresponding 1,5- and 2,5-disubstituted tetrazoles. 2,4′-Dibromoacetophenone gave the corresponding 2,5-disubstituted derivative as the only isomer. Synthesis of tetrazole derivatives with excellent yields in short times, a wide range of products under ultrasound irradiation, environmental benignity and a simple work-up procedure are some of the important features of this protocol.
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