Automatic Control and Directed Cell Movement Novel Approach for Understanding Chemotaxis, Galvanotaxis, Galvanotropism

Author:

Gruler Hans1,Franke Kurt1

Affiliation:

1. Abteilung Biophysik, Universität Ulm , Postfach 40 66, D-7900 Ulm, Bundesrepublik Deutschland

Abstract

Abstract It is shown that chemotaxis, galvanotaxis, galvanotropism , etc. are functions of cells having a goal-seeking system. Even when the involved physicochemical signals are unknown, the cel­lular system can be treated phenomenologically like an automatic controller having a closed-loop feedback system. The model is verified by means of galvanotaxis and chemotaxis data of human granulocytes. The galvanotaxis and chemotaxis coefficient quantifying the cellular sensi­bility can be predicted from the coefficient which characterizes the deterministic part of the signal transduction/response system of the cell divided by the coefficient which characterizes the noise strength in the cellular signal transduction/response system. The model is not restricted to directed movement of granulocytes. It is very general and can be applied to any cell type for directed phenomena like chemotaxis, galvanotaxis, phototaxis, magnetotaxis, directed growth, etc. The virus-disturbed directed migration of granulocytes is discussed and it is shown that the virus alters the deterministic part of the cellular controller.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

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