Affiliation:
1. Abteilung Medizinische Biochemie, Physiologisch-Chemisches Institut Universitätskrankenhaus Eppendorf, Martinistraße 52, 2000 H am burg 20, Bundesrepublik Deutschland
Abstract
Abstract
The inhibitory effect of various oral doses of different hexacyanoferrate(II) compounds (HCF) and the influence of the time interval of HCF-administration on intestinal 134Cs-absorption was studied in rats. Optimum inhibition was obtained by administration of HCF together with or 2 min before oral 134Cs loading. Using appropriate low amounts (0.1 -0.5 mg) of the different HCF compounds, the inhibitory effect increased in the sequence KZnHCF < KCuHCF < FeHCF < KCoHCF = KNiHCF < NH4FeHCF = KFeHCF . Oral administration of 5 mg (0.5 mg) of KFeHCF , together with 134CsCl loading, reduces 134Cs-absorption from 41 % (control) to 0.8% (2.8%).
Zinc-, copper-, cobalt, and nickel hexacyanoferrates(II), despite showing a high caesium sorption capacity in vitro, were less effective in rats and are not suited for in vivo application, also because they may produce toxic side effects. As a consequence, the orally administered colloidal-soluble iron (III) hexacyanoferrates(II) (NH4Fe[Fe(CN)6] and KFe[Fe(CN)6]) have to be considered as the most valuable countermeasure against radiocaesium absorption for humans and domestic animals in the case of a severe nuclear accident in the future.
Manganese oxide, a non-hexacyanoferrate(II) compound with known in vitro caesium binding capacity, showed no inhibitory effect on radiocaesium absorption in rats.
Subject
General Biochemistry, Genetics and Molecular Biology
Cited by
9 articles.
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