Antifungal and Antibacterial Activities of Pentanema divaricatum and Its Active Constituent-Reference-Cited by-同舟云学术

Antifungal and Antibacterial Activities of Pentanema divaricatum and Its Active Constituent

Published:2008-10-01 Issue:9-10 Volume:63 Page:649-652
ISSN:1865-7125
Container-title:Zeitschrift für Naturforschung C
language:en
Short-container-title:

Author:

Momen-Roknabadi Nastaran¹,Gohari Ahamd R.²,Monsef-Esfehani Hamid R.³,Attar Farideh⁴,Hajiaghaee Reza⁵,Saeidnia Soodabeh²,Jamalifar Hossein¹,Kamalinia Golnaz¹,Shahverdi Ahamd R.¹

Affiliation:

1. Department of Pharmaceutical Biotechnology and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Medical Sciences/University of Tehran, Tehran, Iran

2. Medicinal Plants Research Center, Faculty of Pharmacy, Medical Sciences/University of Tehran, Tehran, Iran

3. Department of Pharmacognosy, Faculty of Pharmacy, Medical Sciences/University of Tehran, Tehran, Iran

4. Central Herbarium of Tehran University, Faculty of Biology, Tehran University, Tehran, Iran

5. Department of Pharmacognosy, Institute of Medicinal Plants, ACECR, Tehran, Iran

Abstract

The antimicrobial activity of ethanol and chloroform extracts of Pentanema divaricatum Cass. was studied using the conventional disk diffusion method. The extracts’ highest antimicrobial activity was observed against Aspergillus niger. Bioassay-guided fractionation of the crude extract by preparative thin layer chromatography (PTLC) showed one antimicrobial fraction which was especially effective against Aspergillus niger. By conventional spectroscopy the active fraction was identified as 4α,5α-epoxy-10α,14H-1-epi-inuviscolide. This compound represented the most potent antimicrobial candidate, with MIC values of < 25 μg/disk against A. niger strains and 200 μg/disk against Bacillus cereus and Staphylococcus aureus.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://www.degruyter.com/document/doi/10.1515/znc-2008-9-1006/pdf

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