Untersuchungen zur Charakterisierung des Prochamazulens Matrizin aus Matricaria chamomilla L. / Studies on the Characterization of the Chamazulene Precursor Matricine from Matricaria chamomilla L.

Abstract

The relative configuration of the thermolabile chamazulene precursor matricine has been established by NMR spectrometric studies. The NMR spectral data prove to be consistent with the well-known structure of the chamomile component. On the basis of our results the levorotatory natural substance moreover can be specified stereochemically as (−)-(3S*, 3aR*, 4S*, 9R*, 9aS*, 9bS*)-4-acetoxy-2,3,3a,4,5,9,9a,9b-octahydro-9-hydroxy-3,6,9-trimethylazuleno[4,5-b]furan-2-one.