Synthese und pharmakologische Eigenschaften von 4.4-Diphenyl-4-sila-piperidinen / Synthesis and Pharmalogical Properties of 4,4-Diphenyl-4-sila-piperidines

Abstract

4,4-Diphenyl-4-sila-piperidines 3 a-d and their hydrochlorides 4 a-d could be synthesized by two different methods starting from diphenyldivinylsilane (Scheme 1). Some properties of these compounds are described. They are the silicon analogues of the well known neuropharmaca 10. Preliminary pharmacological investigations show that the sila-compounds 4a-c have interesting affects concerning to the content of neurotransmitter in the homogenate of rat brains and to the bonding to different receptors