Synthese, Organ-Verteilung und cytostatische Wirkung der N-Methyl-N-β-chloräthyl-hydrazone von Metallocen-aldehyden / Synthesis, Biochemistry and Cytostatic Effects of N-Methyl-N-β-chlorethyl-hydrazones of Metallocene Aldehydes

Abstract

Abstract Since the N-Methyl-N-β-chlorethylhydrazone of benzaldehyde has cytostatic effects, the corre­sponding hydrazones of ferrocene-and ruthenocenaldehyde were synthesized. The ruthenocenal-dehyde hydrazone was labelled with 103Ru and its excretion, metabolism and organ-distribution in mice and rats were measured. The hydrazone was metabolized to one main metabolite, which was rapidly excreted in the bile. No evidence for the liberation of ruthenium ions was found. The hydrazone had a very high affinity to lung tissue, a 103Ru-concentration ratio lung/muscle of 600 : 1 was found, but only moderate affinities to liver, kidney and gut. The affinity for thymus, spleen and tumor was low. Both metallocenaldehyde hydrazones showed cytostatic effects, similar to that of benzaldehyde hydrazone.