Diagnosis of IRAK-4-deficiency by flow cytometric measurement of IκB-α degradation

Author:

Frans Glynis12ORCID,Michiels Birthe12ORCID,Picard Capucine3456,Ampofo Louanne7,Raes Marc8,Toelen Jaan9,Bucciol Giorgia910,van der Werff ten Bosch Jutte11,Moens Leen10,Wuyts Greet1,Dillaerts Doreen1,Casanova Jean-Laurent5121314,Schrijvers Rik1516,Meyts Isabelle910,Bossuyt Xavier12

Affiliation:

1. Department of Microbiology, Immunology and Transplantation , Clinical and Diagnostic Immunology, KU Leuven , Leuven , Belgium

2. Department of Laboratory Medicine , University Hospitals Leuven , Leuven , Belgium

3. Necker Medical School, Paris Descartes University , Paris , France

4. Study Center for Primary Immunodeficiencies, Necker-Enfants Malades Hospital, Assistance Publique Hôpitaux de Paris (APHP) , Paris , France

5. Imagine Institute, Paris Descartes University Paris , France

6. Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, AP-HP Paris , France

7. Department of Pharmaceutical and Pharmacological Sciences , Therapeutic and Diagnostic Antibodies, KU Leuven , Leuven , Belgium

8. Department of Pediatrics , Jessa Hospital , Hasselt , Belgium

9. Department of Pediatrics , University Hospitals Leuven , Leuven , Belgium

10. Department of Microbiology, Immunology and Transplantation , Laboratory for Inborn Errors of Immunity, KU Leuven , Leuven , Belgium

11. Department of Pediatrics , Antwerp Hospital Network , Antwerp , Belgium

12. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, and Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children Paris , France

13. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University , New York , NY , USA

14. Howard Hughes Medical Institute , New York , NY , USA

15. Department of Microbiology, Immunology and Transplantation , Allergy and Clinical Immunology Research Group, KU Leuven , Leuven , Belgium

16. Department of General Internal Medicine , University Hospitals Leuven , Leuven , Belgium

Funder

Onderzoeksraad, KU Leuven

Fonds Wetenschappelijk Onderzoek

Jeffrey Modell Foundation

Agentschap voor Innovatie door Wetenschap en Technologie

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,General Medicine

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