Operational considerations and challenges of biochemistry laboratories during the COVID-19 outbreak: an IFCC global survey

Author:

Loh Tze Ping1,Horvath Andrea Rita2,Wang Cheng-Bin3,Koch David4,Adeli Khosrow5,Mancini Nicasio67,Ferrari Maurizio8,Hawkins Robert9,Sethi Sunil10,Lippi Giuseppe11

Affiliation:

1. Department of Laboratory Medicine , National University Hospital , 5 Lower Kent Ridge Road , Singapore 119074 , Singapore , Phone: (+65) 67724345, Fax: (+65) 67771613

2. Department of Clinical Chemistry and Endocrinology, New South Wales Health Pathology , Prince of Wales Hospital , Sydney , Australia

3. Department of Laboratory Medicine , Chinese PLA General Hospital , Beijing , P.R. China

4. Department of Pathology and Laboratory Medicine , Emory University , Atlanta, GA , USA

5. Clinical Biochemistry, The Hospital for Sick Children , University of Toronto , Toronto, ON , Canada

6. Laboratory of Microbiology and Virology , University Vita-Salute San Raffaele , Milan , Italy

7. IRCCS San Raffaele Hospital , Milan , Italy

8. Università Vita-Salute San Raffaele , Milan , Italy

9. Department of Laboratory Medicine , Tan Tock Seng Hospital , Singapore , Singapore

10. Department of Laboratory Medicine , National University Hospital , Singapore , Singapore

11. Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement , University of Verona , Verona , Italy

Abstract

Abstract Objectives The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Task Force on COVID-19 conducted a global survey to understand how biochemistry laboratories manage the operational challenges during the coronavirus disease 2019 (COVID-19) pandemic. Materials and methods An electronic survey was distributed globally to record the operational considerations to mitigate biosafety risks in the laboratory. Additionally, the laboratories were asked to indicate the operational challenges they faced. Results A total of 1210 valid submissions were included in this analysis. Most of the survey participants worked in hospital laboratories. Around 15% of laboratories restricted certain tests on patients with clinically suspected or confirmed COVID-19 over biosafety concerns. Just over 10% of the laboratories had to restrict their test menu or services due to resource constraints. Approximately a third of laboratories performed temperature monitoring, while two thirds of laboratories increased the frequency of disinfection. Just less than 50% of the laboratories split their teams. The greatest reported challenge faced by laboratories during the COVID-19 pandemic is securing sufficient supplies of personal protective equipment (PPE), analytical equipment, including those used at the point of care, as well as reagents, consumables and other laboratory materials. This was followed by having inadequate staff, managing their morale, anxiety and deployment. Conclusions The restriction of tests and services may have undesirable clinical consequences as clinicians are deprived of important information to deliver appropriate care to their patients. Staff rostering and biosafety concerns require longer-term solutions as they are crucial for the continued operation of the laboratory during what may well be a prolonged pandemic.

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,General Medicine

Reference18 articles.

1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020;382:727–33.

2. World Health Organisation. WHO Director-General’s remarks at the media briefing on 2019-nCoV on 11 February 2020. https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020 (Last accessed: 1 May 2020).

3. Lippi G, Plebani M. The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks. Clin Chem Lab Med 2020;58:1063–9.

4. Binnicker MJ. Emergence of a novel coronavirus disease (COVID-19) and the importance of diagnostic testing: why partnership between clinical laboratories, public health agencies, and industry is essential to control the outbreak. Clin Chem 2020;66:664–6.

5. Hawkins R. Preparing the biochemistry laboratory for the next outbreak: lessons from SARS in Singapore. Clin Biochem Rev 2005;26:59–64.

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