Within- and between-subject biological variation data for serum zinc, copper and selenium obtained from 68 apparently healthy Turkish subjects

Author:

Coşkun Abdurrahman12,Carobene Anna3,Aarsand Aasne K.45,Aksungar Fehime B.62,Serteser Mustafa62,Sandberg Sverre758,Díaz-Garzón Jorge910ORCID,Fernandez-Calle Pilar910,Karpuzoğlu Fatma H.62,Coskun Cihan11,Kızılkaya Emine12,Fidan Damla12,Jonker Niels13,Uğur Esra14,Unsal Ibrahim15

Affiliation:

1. EFLM Working Group on Biological Variation; EFLM Task Group for the Biological Variation Database; Department of Medical Biochemistry, School of Medicine, Acibadem Mehmet Ali Aydınlar University , Atasehir , Istanbul , Turkey

2. Acibadem Labmed Clinical Laboratories , Atasehir , Istanbul , Turkey

3. EFLM Working Group on Biological Variation; EFLM Task Group for the Biological Variation Database; and Laboratory Medicine, IRCCS San Raffaele Scientific Institute , Milan , Italy

4. EFLM Working Group on Biological Variation; EFLM Task Group for the Biological Variation Database; Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital , Bergen , Norway

5. Norwegian Organization for Quality Improvement of Laboratory Examinations (NOKLUS), Haraldsplass Deaconess Hospital , Bergen , Norway

6. Department of Medical Biochemistry, School of Medicine, Acibadem Mehmet Ali Aydınlar University, Atasehir , Istanbul , Turkey

7. EFLM Working Group on Biological Variation; EFLM TaskGroup for the Biological Variation Database; Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital , Bergen , Norway

8. Department of Global Health and Primary Care, Faculty of Medicine, University of Bergen , Bergen , Norway

9. EFLM Working Group on Biological Variation; EFLM Task Group for the Biological Variation Database; Department of LaboratoryMedicine, La Paz University Hospital , Madrid , Spain

10. Analytical Quality Commission, Spanish Society of Laboratory Medicine (SEQCML) , Barcelona , Spain

11. Department of Medical Biochemistry, Basaksehir Cam and Sakura City hospital, Basaksehir , Istanbul , Turkey

12. School of Medicine, Acibadem Mehmet Ali Aydınlar University , Atasehir , Istanbul , Turkey

13. EFLM Working Group on Biological Variation; EFLMTask Group for the Biological Variation Database; and Certe, Wilhelmina Ziekenhuis Assen , Assen , The Netherlands

14. School of Health Science, Acibadem Mehmet Ali Aydınlar University, Atasehir , Istanbul , Turkey

15. Acibadem Labmed Clinical Laboratories, Atasehir , Istanbul , Turkey

Abstract

Abstract Objectives Trace elements (TrEL) are nutritionally essential components in maintaining health and preventing diseases. There is a lack of reliable biological variation (BV) data for TrELs, required for the diagnosis and monitoring of TrEL disturbances. In this study, we aimed to provide updated within- and between-subject BV estimates for zinc (Zn), copper (Cu) and selenium (Se). Methods Weekly serum samples were drawn from 68 healthy subjects (36 females and 32 males) for 10 weeks and stored at −80 °C prior to analysis. Serum Zn, Cu and Se levels were measured using inductively-coupled plasma mass spectrometry (ICP-MS). Outlier and variance homogeneity analyses were performed followed by CV-ANOVA (Røraas method) to determine BV and analytical variation estimates with 95% CI and the associated reference change values (RCV) for all subjects, males and females. Results Significant differences in mean concentrations between males and females were observed, with absolute and relative (%) differences for Zn at 0.5 μmol/L (3.5%), Cu 2.0 μmol/L (14.1%) and Se 0.06 μmol/L (6.0%). The within-subject BV (CVI [95% CI]) estimates were 8.8% (8.2–9.3), 7.8% (7.3–8.3) and 7.7% (7.2–8.2) for Zn, Cu and Se, respectively. Within-subject biological variation (CVI) estimates derived for male and female subgroups were similar for all three TrELs. Marked individuality was observed for Cu and Se. Conclusions The data of this study provides updated BV estimates for serum Zn, Cu and Se derived from a stringent protocol and state of the art methodologies. Furthermore, Cu and Se display marked individuality, highlighting that population based reference limits should not be used in the monitoring of patients.

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,General Medicine

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