Serial measurement of circulating calprotectin as a prognostic biomarker in COVID-19 patients in intensive care setting
Author:
Nevejan Louis12ORCID, Strypens Thomas12, Van Nieuwenhove Mathias34, Boel An1, Cattoir Lien1, Van Vaerenbergh Kristien1, Meeus Peter1, Bossuyt Xavier25, De Neve Nikolaas34, Van Hoovels Lieve15ORCID
Affiliation:
1. Department of Laboratory Medicine , OLV Hospital , Aalst , Belgium 2. Department of Laboratory Medicine , University Hospital Leuven , Leuven , Belgium 3. Department of Intensive Care Medicine , OLV Hospital , Aalst , Belgium 4. Department of Anesthesiology , OLV Hospital , Aalst , Belgium 5. Department of Microbiology, Immunology and Transplantation , KU Leuven , Leuven , Belgium
Abstract
Abstract
Objectives
Circulating calprotectin (cCLP) has been shown to be a promising prognostic marker for COVID-19 severity. We aimed to investigate the prognostic value of serial measurements of cCLP in COVID-19 patients admitted to an intensive care unit (ICU).
Methods
From November 2020 to May 2021, patients with COVID-19, admitted at the ICU of the OLV Hospital, Aalst, Belgium, were prospectively included. For sixty-six (66) patients, blood samples were collected at admission and subsequently every 48 h during ICU stay. On every sample (total n=301), a cCLP (EliA™ Calprotectin 2, Phadia 200, Thermo Fisher Scientific; serum/plasma protocol (for Research Use Only, -RUO-) and C-reactive protein (CRP; cobas c501/c503, Roche Diagnostics) analysis were performed. Linear mixed models were used to associate biomarkers levels with mortality, need for mechanical ventilation, length of stay at ICU (LOS-ICU) and medication use (antibiotics, corticosteroids, antiviral and immune suppressant/modulatory drugs).
Results
Longitudinally higher levels of all biomarkers were associated with LOS-ICU and with the need for mechanical ventilation. Medication use and LOS-ICU were not associated with variations in cCLP and CRP levels. cCLP levels increased significantly during ICU hospitalization in the deceased group (n=21/66) but decreased in the non-deceased group (n=45/66). In contrast, CRP levels decreased non-significantly in both patient groups, although significantly longitudinally higher CRP levels were obtained in the deceased subgroup.
Conclusions
Serial measurements of cCLP provides prognostic information which can be useful to guide clinical management of COVID-19 patients in ICU setting.
Publisher
Walter de Gruyter GmbH
Subject
Biochemistry (medical),Clinical Biochemistry,General Medicine
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