Capillary blood parameters are gestational age, birthweight, delivery mode and gender dependent in healthy preterm and term infants-Reference-Cited by-同舟云学术

Capillary blood parameters are gestational age, birthweight, delivery mode and gender dependent in healthy preterm and term infants

Published:2024-08-23 Issue: Volume: Page:
ISSN:1434-6621
Container-title:Clinical Chemistry and Laboratory Medicine (CCLM)
language:en
Short-container-title:

Author:

Perrotta Marika¹,D’Adamo Ebe¹,Strozzi Chiara²,D’Egidio Claudia¹,Del Rosso Francesca¹,Maconi Antonio³,Picone Simonetta⁴,Giardinelli Giustina¹,Cepelli Laura¹,Cicolini Ilenia¹,Conte Mariangela¹,Bellinaso Mariangela⁵,Negri Rossana⁵,Gazzolo Francesca⁶,Cassinari Maurizio⁷,Abella Laura⁸,Abdelhameed Ali Saber⁹,Mangifesta Rocco¹⁰,Gazzolo Diego¹

Affiliation:

1. Neonatal Intensive Care Unit G d’Annunzio University of Chieti , Chieti , Italy

2. Ospedale Cardinal Massaia , Asti , Italy

3. Social Security Administration Development and Promotion of Scientific Research Unit , SS Antonio, Biagio and C. Arrigo Hospital , Alessandria , Italy

4. Neonatology and Neonatal Intensive Care Unit , Policlinico Casilino General Hospital , Rome , Italy

5. Neonatal Intensive Care Unit , SS Antonio, Biagio and C. Arrigo Hospital , Alessandria , Italy

6. Magna Graecia University , Catanzaro , Italy

7. Department of Clinical Biochemistry , Transfusion and Regeneration Medicine Alessandria Hospital , Alessandria , Italy

8. Hospital Universitari Dexeus , Barcelona , Spain

9. Department of Pharmaceutical Chemistry, College of Pharmacy , King Saud University , Riyadh , Saudi Arabia

10. Health and Safety Manager, ASL2 Abruzzo , Chieti , Italy

Abstract

Abstract Objectives The measurement of blood pH and gas analytes (BPGA), soon after birth, constitutes the first-line standard of care procedure in high-risk newborns. However, no data is available in capillary blood on perinatal bias such as gestational age (GA), weight at birth (BW), delivery mode, and gender. The aims of the present study were to investigate whether in a cohort of healthy preterm (PT) and term (T) infants BPGA were GA, BW, delivery mode and gender dependent, thus affecting BPGA reliability as diagnostic test. Methods We performed a prospective case-control study in 560 healthy infants (PT: n=115, T: n=445). BPGA was measured within 24-h from birth. Perinatal characteristics, outcomes, and clinical examination were also recorded. Results PT infants showed higher (p<0.001) carbon dioxide partial pressure (pCO2), fraction of fetal hemoglobin (HbF), base excess (BE), bicarbonate (HCO3), and lower lactate (Lac) levels. When corrected for delivery mode, higher (p<0.001) HbF, BE, HCO3, and lower Lac levels were found. Similarly, higher (p<0.05, for all) pCO2, HbF, BE, HCO3 and lower Lac levels were found between female and male PT and T infants. Repeated multiple logistic regression analysis showed that BPGA was GA, BW, delivery mode and gender dependent. Conclusions The present results showing that BPGA can be affected by a series of perinatal outcomes open the way to further investigations providing longitudinal BPGA reference curves in the transitional phase, thus empowering BPGA role as a reliable diagnostic and therapeutic strategies efficacy marker.

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/cclm-2024-0821/pdf

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