Discriminating signal from noise: the biological variation of circulating calprotectin in serum and plasma

Author:

Briers Marth12,Massa Bo12ORCID,Vander Cruyssen Bert3,Van Den Bremt Stefanie1,Hofman Laura1,Van Langenhove Leen4,Hoermann Bernhard5ORCID,Bossuyt Xavier26ORCID,Van Hoovels Lieve16ORCID

Affiliation:

1. Department of Laboratory Medicine , OLV Hospital , Aalst , Belgium

2. Department of Laboratory Medicine , University Hospital Leuven , Leuven , Belgium

3. Department of Rheumatology , OLV Hospital , Aalst , Belgium

4. I-BioStat, KU Leuven , Leuven , Belgium

5. Thermo Fisher Scientific , Freiburg , Germany

6. Department of Microbiology, Immunology and Transplantation , KU Leuven , Leuven , Belgium

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,General Medicine

Reference10 articles.

1. Manfredi, M, Van Hoovels, L, Benucci, M, De Luca, R, Coccia, C, Bernardini, P, et al.. Circulating calprotectin (cCLP) in autoimmune diseases. Autoimmun Rev 2023;22:103295. https://doi.org/10.1016/j.autrev.2023.103295.

2. Choi, IY, Gerlag, DM, Herenius, MJ, Thurlings, RM, Wijbrandts, CA, Foell, D, et al.. MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis. Ann Rheum Dis 2015;74:499–505. https://doi.org/10.1136/annrheumdis-2013-203923.

3. Nordal, HH, Brokstad, KA, Solheim, M, Halse, AK, Kvien, TK, Hammer, HB. Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis. Arthritis Res Ther 2017;19:3. https://doi.org/10.1186/s13075-016-1201-0.

4. Andres Cerezo, L, Mann, H, Pecha, O, Plestilova, L, Pavelka, K, Vencovsky, J, et al.. Decreases in serum levels of S100A8/9 (calprotectin) correlate with improvements in total swollen joint count in patients with recent-onset rheumatoid arthritis. Arthritis Res Ther 2011;13:R122. https://doi.org/10.1186/ar3426.

5. Hurnakova, J, Hulejova, H, Zavada, J, Komarc, M, Hanova, P, Klein, M, et al.. Serum calprotectin discriminates subclinical disease activity from ultrasound-defined remission in patients with rheumatoid arthritis in clinical remission. PLoS One 2016;11:e0165498. https://doi.org/10.1371/journal.pone.0165498.

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