Early changes in S100B maternal blood levels can predict fetal intrauterine growth restriction-Reference-Cited by-同舟云学术

Early changes in S100B maternal blood levels can predict fetal intrauterine growth restriction

Published:2023-06-28 Issue:12 Volume:61 Page:2205-2211
ISSN:1434-6621
Container-title:Clinical Chemistry and Laboratory Medicine (CCLM)
language:en
Short-container-title:

Author:

Abella Laura¹,D’Adamo Ebe²,Strozzi Mariachiara³,Botondi Valentina²,Abella Ernesto⁴,Cassinari Maurizio³,Mazzucco Laura³,Maconi Antonio³,Testa Michela³,Zanelli Cristian³,Patacchiola Roberta⁵,Librandi Michela⁵,Osmelli Jacopo⁵,Carabotta Maura⁵,Chiarelli Francesco⁵,Gazzolo Diego²

Affiliation:

1. Hospital Universitari Dexeus , Barcelona , Spain

2. Neonatal Intensive Care Unit , G. d’Annunzio University , Chieti , Italy

3. Neonatal Intensive Care Unit , ASO SS Antonio, Biagio, C. Arrigo , Alessandria , Italy

4. Hospital Dr. Max Peralta Jimènez , Cartago , Costa Rica

5. Department of Pediatrics , University of Chieti , Chieti , Italy

Abstract

Abstract Objectives Intrauterine growth restriction (IUGR) represents one of the main causes of perinatal mortality and morbidity. Nowadays, IUGR early diagnosis is mandatory in order to limit the occurrence of multiorgan failure, especially the brain. Therefore, we investigated whether longitudinal S100B assessment in maternal blood could be a trustable predictor of IUGR. Methods We conducted a prospective study in 480 pregnancies (IUGR: n=40; small for gestational age, SGA: n=40; controls: n=400) in whom S100B was measured at three predetermined monitoring time-points (T1: 8–18 GA; T2: 19–23 GA; T3: 24–28 GA). Results Lower S100B in IUGR fetuses than SGA and controls (p<0.05, for all) at T1–T3. Receiver operating characteristic curve showed that S100B at T1 was the best predictor of IUGR (sensitivity: 100 %; specificity: 81.4 %) than T2, T3. Conclusions The early lower S100B concentration in pregnant women lately complicated by IUGR support the notion that non-invasive early IUGR diagnosis and monitoring is becoming feasible. Results open the way to further studies aimed at diagnosing and monitoring fetal/maternal diseases at earliest time.

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,General Medicine

Link

https://www.degruyter.com/document/doi/10.1515/cclm-2023-0294/pdf

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