Elevated S100B urine levels predict seizures in infants complicated by perinatal asphyxia and undergoing therapeutic hypothermia-Reference-Cited by-同舟云学术

Elevated S100B urine levels predict seizures in infants complicated by perinatal asphyxia and undergoing therapeutic hypothermia

Published:2024-01-30 Issue:6 Volume:62 Page:1109-1117
ISSN:1434-6621
Container-title:Clinical Chemistry and Laboratory Medicine (CCLM)
language:en
Short-container-title:

Author:

Bersani Iliana¹,Lapergola Giuseppe²,Patacchiola Roberta²,D’Adamo Ebe²,Stuppia Liborio³,de Laurenzi Vincenzo³,Damiani Verena³,Cataldo Ivana⁴,Clemente Katia⁴,Primavera Adele²,Salomone Rita²,Barbante Elisabetta²,Campi Francesca¹,Savarese Immacolata¹,Ronci Sara¹,Dotta Andrea¹,Braguglia Annabella¹,Longo Daniela¹,Gavilanes Danilo A.W.⁵,Gazzolo Francesca⁶,Serpero Laura⁷,Strozzi Maria Chiara⁸,Maconi Antonio⁹,Cassinari Maurizio¹⁰,Libener Roberta¹⁰,Gazzolo Diego²

Affiliation:

1. Department of Neonatology , Neonatal Intensive Care Unit, Bambino Gesù Children’s Hospital , Rome , Italy

2. Neonatal Intensive Care Unit, G. d’Annunzio University of Chieti , Chieti , Italy

3. Center for Advances Studies and Technology (CAST), G. d’Annunzio University , Chieti , Italy

4. Laboratory of Clinical Pathology, SS Annunziata Hospital , Chieti , Italy

5. Department of Pediatrics and Neonatology , Maastricht University , Maastricht , The Netherlands

6. Magna Graecia University , Catanzaro , Italy

7. Department of Maternal, Fetal and Neonatal Medicine , SS Antonio, Biagio and C. Arrigo Hospital , Alessandria , Italy

8. Department of Pediatrics and Neonatology , Ospedale Cardinal Massaia , Asti , Italy

9. Social Security Administration Development and Promotion of Scientific Research Unit, SS Antonio, Biagio and C. Arrigo Hospital , Alessandria , Italy

10. Department of Clinical Biochemistry , Transfusion and Regeneration Medicine Alessandria Hospital , Alessandria , Italy

Abstract

Abstract Objectives Seizures (SZ) are one of the main complications occurring in infants undergoing therapeutic hypothermia (TH) due to perinatal asphyxia (PA) and hypoxic ischemic encephalopathy (HIE). Phenobarbital (PB) is the first-line therapeutic strategy, although data on its potential side-effects need elucidation. We investigated whether: i) PB administration in PA-HIE TH-treated infants affects S100B urine levels, and ii) S100B could be a reliable early predictor of SZ. Methods We performed a prospective case-control study in 88 PA-HIE TH infants, complicated (n=44) or not (n=44) by SZ requiring PB treatment. S100B urine levels were measured at 11 predetermined monitoring time-points from first void up to 96-h from birth. Standard-of-care monitoring parameters were also recorded. Results S100B significantly increased in the first 24-h independently from HIE severity in the cases who later developed SZ and requested PB treatment. ROC curve analysis showed that S100B, as SZ predictor, at a cut-off of 2.78 μg/L achieved a sensitivity/specificity of 63 and 84 %, positive/negative predictive values of 83 and 64 %. Conclusions The present results offer additional support to the usefulness of S100B as a trustable diagnostic tool in the clinical daily monitoring of therapeutic and pharmacological procedures in infants complicated by PA-HIE.

Publisher

Walter de Gruyter GmbH

Link

https://www.degruyter.com/document/doi/10.1515/cclm-2023-1471/pdf

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