The role of neuroimmune interactions in musculoskeletal pain-Reference-Cited by-同舟云学术

The role of neuroimmune interactions in musculoskeletal pain

Published:2022-03-23 Issue:2 Volume:28 Page:77-84
ISSN:0947-0875
Container-title:Neuroforum
language:en
Short-container-title:

Author:

Schaible Hans-Georg¹^ORCID,Ebersberger Andrea¹^ORCID,Natura Gabriel¹^ORCID,Vazquez Enrique¹^ORCID

Affiliation:

1. Institute of Physiology 1/Neurophysiology, Jena University Hospital , Teichgraben 8 , 07743 Jena , Germany

Abstract

Abstract Interactions of the immune system and the nociceptive system play an important role in the generation and maintenance of pain in musculoskeletal diseases and in disease development. In inflamed tissue peripheral nociceptive neurons are rendered hyperexcitable by proinflammatory cytokines, antigen/antibody complexes and other immune mediators. Spinal nociceptive neurons are rendered hyperexcitable with the support of microglial cells, the immune cells of the central nervous system. The so-elicited sensitization of pain pathways has a strong impact on pain processing in the brain. On the other hand, immune processes are regulated by the nervous system. Sensory neurons, by releasing neuropeptides, and efferent neurons of the sympathetic nervous system support immune processes which promote disease development.

Publisher

Walter de Gruyter GmbH

Subject

Neurology (clinical),Neurology

Link

https://www.degruyter.com/document/doi/10.1515/nf-2022-0001/pdf

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