Abspaltung säurelabiler Aminoschutzgruppen durch Pyridiniumsalze / The Removal of Acid-labile Amino-protecting Groups by Pyridinum Salts

Abstract

Pyridinium salts of strong acids are usefull reagents in organic solvents, e. g. methanol, for the selective cleavage of acid labile amino-protecting groups as the trityl, o-nitrophenylsulfenyl, and the 2-(ρ-biphenyl)-isopropyloxycarbonyl residue. The cleavage reactions are investigated with respect to time, temperature, concentration of the reagent, different solvents, different pyridinium salts with and without addition of indole, and sterically hindrance by the structure of the amino acids.