Morphopathological and immunohistochemical features of a pure mucinous breast carcinoma

Morphopathological and immunohistochemical features of a pure mucinous breast carcinoma – Case report

Published:2016-08-01 Issue:3 Volume:22 Page:174-180
ISSN:1841-4036
Container-title:ARS Medica Tomitana
language:en
Short-container-title:

Author:

Aschie Mariana¹²³,Baltatescu Gabriela Izabela³,Cozaru Georgeta Camelia³,Mitroi Anca³,Enciu Manuela²³

Affiliation:

1. Associated member of Academy of Romanian Scientists

2. Department of Pathology, Faculty of Medicine, “Ovidius” University, Constanta

3. Clinical Service of Pathology, Emergency County Hospital “Sf. Apostol Andrei” Constanta

Abstract

Abstract Pure mucinous carcinoma is a rare special type of breast carcinoma with a 2% incidence and it is usualy asociated with a good prognosis. It must distingished from the mixed subtype of mucinos breast carcinoma, which has an invasive non-mucinous component in more than 10% of the tumor and change the favourable outcome of the first subtype. In this report we present a case of a premenopausal woman with a lump in right breast wich histopathologically proved to be a pure mucinous carcinoma associated with high grade ductal carcinoma in situ. Immunohistochemical and ancillary studies demonstrate a great heterogeneity of the neoplastic cells, with different molecular profile for each component of the tumor. The presence of ductal carcinoma in situ with a different imunophenotype from pure mucinous carcinoma rise the ipothesis of a different tumor cell biology which may change clincal evolution.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

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