The Effect of Erythropoietin on Testosterone Levels During Ischemia Reperfusion Injury in Rats-Reference-Cited by-同舟云学术

The Effect of Erythropoietin on Testosterone Levels During Ischemia Reperfusion Injury in Rats

Published:2016-11-01 Issue:4 Volume:22 Page:264-269
ISSN:1841-4036
Container-title:ARS Medica Tomitana
language:en
Short-container-title:

Author:

Tsompos C.¹,Panoulis C.²,Toutouzas K.³,Aggeliki Triantafyllou⁴,Zografos G.³,Papalois A.⁵

Affiliation:

1. Department of Obstetrics & Gynecology, Mesologi County Hospital, Etoloakarnania, Greece

2. Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki, Greece

3. Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece

4. Department of Biologic Chemistry, Athens University, Attiki, Greece

5. Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Attiki, Greece

Abstract

Abstract Objective: This experimental study examined the effect of erythropoietin (Epo) in a rat model and particularly in an adrenal ischemia-reperfusion (IR) protocol. The effect of that molecule was studied biochemically using blood mean testosterone levels (T). Materials and methods: 40 rats of mean weight 247.7 g were used in the study. T levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion. Erythropoietin was administered only in groups C and D. Results: Erythropoietin administration non significantly increased the testosterone levels by 71.21%+44.19% (p=0.1080). Reperfusion time non-significantly decreased the testosterone levels by 65.17%+44.45% (p=0.0792). However, erythropoietin administration and reperfusion time together produced a non-significant combined effect in increasing the testosterone levels by 27.65%+27.21% (p= 0.3006). Conclusions: Erythropoietin administration whether it interacted or not with reperfusion time has increasing non significant short-term effects on testosterone levels. Perhaps, a longer study time or a higher Epo dose, may reveal clearer and more significant effects.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

Reference11 articles.

1. 1. Tsompos, C., Panoulis, C., Toutouzas, K., Triantafyllou, A., Zografos, G. & Papalois, A. (2016). The effect of erythropoietin on calcium levels during hypoxia reoxygenation injury in rats. Geriatric care 2:5722:12-16.

2. 2. Tsompos, C., Panoulis, C., Toutouzas, K., Zografos, G. & Papalois, A. (2015). The effect of erythropoietin on albumins levels during hypoxia reoxygenation injury in rats. Research Journal of Pharmacology and Toxicology 1(3):42-45.

3. 3. Tsompos, C., Panoulis, C., Toutouzas, K., Triantafyllou, A., Zografos, G. & Papalois, A. (2016). The Effect of Erythropoietin on Aspartate Aminotransferase Levels during Ischemia Reperfusion Injury in Rats. Electronic Journal of Biology 12(2): 161-167.

4. 4. Tsompos, C., Panoulis, C., Toutouzas, K., Triantafyllou, A., Zografos, G. & Papalois, A. (2016). The acute trend of erythropoietin on platelet count during hypoxia reoxygenation injury in rats. Medical Channel Karachi 22 (1),7-13.

5. 5. Tsompos, C., Panoulis, C., Toutouzas, K., Zografos, G. & Papalois, A. (2016). The acute effect of erythropoietin on mean corpuscular hemoglobin concentration levels during hypoxia - reoxygenation injury in rats. J Med Soc 30, 79-83.